THE NEXT GENERATION OF GENOME EDITING
New Technologies to Unlock New Frontiers in Genetic Medicine
MISSION
We're Dedicated to Unlocking the Full Potential of Genetic Medicines
Revision is creating novel gene editing technologies to create curative, best-in-class genetic medicines. Revision's technologies improve upon and expand the state-of-the-art in gene editing, opening up unprecedented opportunities for therapeutic development
TECHNOLOGIES
Revision Bio is Developing Novel, Proprietary DNA Polymerase-Based
and DNA Ligase-Based Genome Editing Systems
Best-in-Class Genome Editing Toolkit
Relative to predecessor technologies, Revision Bio's 3D Editing and Ligase Editing offer multiple advantages:
-
Higher Processivity and Fidelity than Reverse Transcriptase-based systems
-
Capable of Larger Insertions than competing gene writing approaches
-
Broad versatility with the capability to execute the full breadth of DNA edits
-
Amenability to validated DNA chemistries to enhance guide stability and potency
-
Wholly-owned with no academic IP obligations
3D Editing
3D Editing pairs the specificity of a DNA-binding protein with the processivity and fidelity of a DNA-Dependent DNA Polymerase
3D Editing is broadly applicable across transitions, transversions, insertions, and deletions
Revision's proprietary single guide architecture represents a significant advance over other disclosed DNA-Dependent DNA Polymerase-based gene editing technologies
Ligase Editing
Ligase Editing pairs the specificity of a DNA-binding protein with the efficiency of a DNA Ligase
Ligase Editing is broadly applicable across small edits and larger insertions / deletions
Revision's proprietary single guide architecture represents a significant advance over other disclosed DNA Ligase-based editing technologies
WHY REVISION
Connect with Us to Discover the Potential of 3D and Ligase Editing
Exploiting the full breadth of opportunities unlocked by Revision Bio's gene editing will require partnership and collaboration. We would welcome an opportunity to tell you more about us and explore ways in which we could work together to bring curative genetic medicines to patients